A Spectular Article: A Heart Surgeon Repeats Hippocrates' Observations

Donald Miller, a cardiac surgeon and professor of medicine, has written a spectacular article, The Trouble with Government Grants, which describes just how corrupt, out of touch with reality, often useless and even harmful, what passes for medical research has become.

The bottom line is that the medical discoveries that really serve humanity do not, and have never, come in discrete packets, but have always been due to great minds making breakthroughs. For example, Albert Einstein was working as a patent clerk at the time he rewrote the physics books. The problem when a government puts x amount of dollars into research, is that it attracts second and third rate minds like rotting flesh attracts maggots, is that because such people rarely if ever make huge breakthroughs, and depend on an absence of breakthroughs for their subsistence, what ostensibly is a constituency for medical discoveries rapidly becomes a constituency against medical discoveries.

This is nothing new, here are Hippocrates' thoughts on the matter:

The Law of Hippocrates

MEDICINE is of all the arts the most noble; but, owing to the ignorance of those who practice it, and of those who, inconsiderately, form a judgment of them, it is at present far behind all the other arts. Their mistake appears to me to arise principally from this, that in the cities there is no punishment connected with the practice of medicine (and with it alone) except disgrace, and that does not hurt those who are familiar with it. Such persons are like the figures which are introduced in tragedies, for as they have the shape, and dress, and personal appearance of an actor, but are not actors, so also physicians are many in title but very few in reality.

2. Whoever is to acquire a competent knowledge of medicine, ought to be possessed of the following advantages: a natural disposition; instruction; a favorable position for the study; early tuition; love of labor; leisure. First of all, a natural talent is required; for, when Nature leads the way to what is most excellent, instruction in the art takes place, which the student must try to appropriate to himself by reflection, becoming an early pupil in a place well adapted for instruction. He must also bring to the task a love of labor and perseverance, so that the instruction taking root may bring forth proper and abundant fruits.

3. Instruction in medicine is like the culture of the productions of the earth. For our natural disposition, is, as it were, the soil; the tenets of our teacher are, as it were, the seed; instruction in youth is like the planting of the seed in the ground at the proper season; the place where the instruction is communicated is like the food imparted to vegetables by the atmosphere; diligent study is like the cultivation of the fields; and it is time which imparts strength to all things and brings them to maturity.

4. Having brought all these requisites to the study of medicine, and having acquired a true knowledge of it, we shall thus, in traveling through the cities, be esteemed physicians not only in name but in reality. But inexperience is a bad treasure, and a bad fund to those who possess it, whether in opinion or reality, being devoid of self-reliance and contentedness, and the nurse both of timidity and audacity. For timidity betrays a want of powers, and audacity a lack of skill. They are, indeed, two things, knowledge and opinion, of which the one makes its possessor really to know, the other to be ignorant.

5. Those things which are sacred, are to be imparted only to sacred persons; and it is not lawful to impart them to the profane until they have been initiated in the mysteries of the science.

Ralph Moss, Dean Burk, and Your Precious Bodily Fluids

As previously blogged, Ralph Moss was a PhD working at Sloan-Kettering until he and elements of senior management developed irreconcilable differences of opinion and went their separate ways. After he left Sloan-Kettering, his interest in cancer research undiminished, he befriended Albert Szent-Györgyi, whose theories about and understandings of cancer have already graced this blog.

Ralph Moss also befriended Dean Burk, a biochemist, who, among other things, co-discovered a B Vitamin, played a role in the invention of the MRI, studied with two Nobel Laureates, and more. One of these Nobel Laureates, with whom Dean Burk became an extremely close friend, was Otto Warburg, who also had an extremely interesting life. An MD, a PhD, who won the Iron Cross, second class, and two Nobel Prizes, (unfortunately at the time he won the second, it was considered unGerman to accept a Nobel Prize), a distinguished cancer researcher, whose ideas are coming back into fashion.

Warburg stayed in Germany and kept his job at the Kaiser Wilhelm Institute during the Nazi years despite the fact that his father had been of Jewish origin. The reason for this, the grapevine has it, was that very high-ranking Nazis, if not their leader himself, believed that he was on the cusp of finding a cure for cancer, and wanted to keep him close by, in case they, or their friends or family should need his ministrations. When laws were passed that banned Germany's Jews, and those with a parent of Jewish origin, from its universities, the highest echelons of the Nazi party saw to it that their office responsible for determining racial "purity" "reassessed" Warburg's Jewish background and reported that only one grandparent had been of Jewish ancestry, which, to poisoned minds meant that he was to be left alone. And thus, right to the end of the war, Warburg had a lab wherein he could do his research oblivious to the clash of arms all around him.

One of Burk's passions was the fight against fluoridation. When Dr. John Yiamouyiannis PhD first approached Burk and told him that there was evidence that suggested that adding fluoride to drinking water was an utter catastrophe for public health, Burk all but urged him to get lost, because he'd been at the Kaiser Wilhelm Institute when the initial studies had been done that had concluded that it was safe. Yiamouyiannis dared Burk to examine his data and tell him where he'd gone wrong; Burk did so, agreed that he had to be right, and, convinced that water fluoridation accounts for tens of thousands of deaths per year in the United States, began his crusade against fluoridating public water supplies. Among other accomplishments, he was able to convince the Dutch and Australian authorities to end their fluoridation programs.

Here are Ralph Moss's recollections of Dean Burk.

You may, of course, be asking yourself, why would anyone ever put anything into the drinking water if there is any doubt at all that it is poisonous. The answer is that fluoride is a byproduct of the production of aluminum, uranium and some fertilizers. A few studies and scientists with a distinct whiff of "liars for hire," transformed what would otherwise have been a hazardous byproduct requiring expensive disposal into an expensive asset that the tax-payer in some countries is forced to buy, pay to put into his drinking water, and then ingest.

If you find this hard to believe, watch this incomparable video.

If you want more information, here is a good starting point.

Ralph Moss, Electron Acceptors, and Cancer

For a few decades a few scientists, some of them Nobel laureates, have believed that antioxidants may prevent and even help to treat cancer. Some of the ideas and clinical results have been very promising, but have not received the attention they deserve. Even worse, unsubstantiated and even false claims have been bandied about by some of those who claim to know everything about the antioxidants, which has served to make anyone who touches the subject appear to be disreputable.

The scientist who probably put the most effort into studying cancer and what antioxidants can do to treat it probably was Albert von Szent-Györgyi, some of whose ideas are described in previous posts. Szent-Györgyi certainly had a colorful life. He was married four times; one marriage already troubled by his wife's increasing dominance developed, as they say, "irreconcilable differences" when he was shocked to catch his wife in bed - with another woman. He twice entered into matrimony at an age at which he would have qualified for membership in the AARP if not Social Security payments. But then again, he enjoyed excellent health, and continued working into his 90s, an achievement he attributed to his consuming sizable quantities of Vitamin C and wheat germ, which is very rich in Vitamin E, daily.

The scion of a illustrious family of doctors, Szent-Györgyi studied medicine in Budapest; his first research was of the structure of the skin around the anus; a doctor uncle of his, afflicted with hemorrhoids, had stipulated that he do so in the hope that his nephew's work might help him overcome his painful condition. During the First World War, Szent-Györgyi served with distinction, until he came to conclusion that the war was a fraud; that Europe's old men were wasting Europe's youth on their vanity. Not keen to die for a useless cause, and keen to save his talents for medical research, he shot himself in the arm, reported it as enemy action, and thus escaped from the war. After the war, he wound up at a university in Holland, where at one point his financial conditions was so bleak that he seriously mulled suicide. The tides of fortune changed; he wound up studying biochemistry at Cambridge and then teaching it in Hungary. He came extremely close to identifying the citric acid cycle now known as as the Krebs Cycle, after Sir Hans Krebs who beat him to the discovery. He was the first scientist to isolate Vitamin C from the paprikas for which Hungary is famous, a discovery that earned him the Nobel Prize.

During the 1930s and 1940s he was the rector of the University of Szeged, had some confrontations with the Hungary's pro-Nazi elements, worked as a secret agent for the British during the war, disappeared when he heard that Adolf Hitler literally wanted his head because he'd tried to broker a deal in which Hungary's would have left the war and joined the Allies, was offered the presidency of Hungary by the Russians after they possessed Hungary. After six fruitless months of trying to reach some reasonable modus vivendi with the Russians, Szent-Györgyi left Hungary for the United States, where he ultimately co-founded the National Center for Cancer Research, and spent his last decades pondering cancer as an electronic syndrome, as previously blogged.

One of Szent-Györgyi's close friends was Ralph Moss, who obtained a PhD in Classics at Stanford University before he found employment as a science writer at Sloan-Kettering. He eventually found the atmosphere at Sloan-Kettering uncongenial - science fiction was not his avocation - and left to devote his time to studying and writing about alternatives in medicine; it was on this quest that he met and befriended Szent-Györgyi, and learned about his understandings of cancer and wayward electrons. Moss wrote an excellent biography of Albert Szent-Györgyi, which is well worth reading.

Electron acceptors, which prevent electron donors from donating their electrons to other molecules, or oxidizing them, are, of course, also known as antioxidants. One of Moss's books "Antioxidants Against Cancer" is about the scientific basis for recommending, or not recommending, antioxidants to cancer patients. He's done a first-rate job of poring through myriad journals and papers and establishing which ideas about the use of antioxidants have a solid scientific basis; he references no less than 460 papers on the subject, in other words, every contention is well documented. It certainly isn't a rah-rah book; Moss carefully explains that certain antioxidants are known to worsen certain cancers; this is a field in which carelessness is particularly disastrous.

Dr. Moss's book is full to tidbits that I would desperately want to know if I were fighting cancer; for example:

• Scientists at the National Institutes of Health conducted a 1,300 patient study that looked into whether a low dose of selenium had any effect on the rate of skin cancer in people with a history of skin cancer over a span of 8 years. The results didn't reveal any significant difference in skin cancer rates; but when they looked at the rates of other cancers, the group taking selenium had a death rate from the more serious cancers such as those of lung, colon, rectum and prostrate that was half of the death rate in the placebo group! Rates of prostrate cancer dropped by 63%!
  

• In a study too small to allow any general conclusions to be drawn, one case of breast cancer went into regression when the patient dramatically increased the dosage of the antioxidant she took of her own accord. In another case, a case of liver cancer with metastases cleared up when the same antioxidant was administered. Regrettably, this phenomenon hasn't been studied in sufficient detail to allow scientists to draw any conclusive conclusions, much less make any recommendations.

• One chemotherapy medication was found to decrease cancer growth by 37%, but when given together with an antioxidant, the decrease in cancer growth was 85%.

I don't want to excerpt Dr. Moss's entire book, but I do know that if I had cancer, I would definitely want to consult his book. Dr. Moss also runs an information service through which advises interested patients about his ideas about alternatives in the treatment of cancer.



Links:


Dr. Moss's website: www.cancerdecisions.com

Dr. Moss's gives Grand Rounds at the University of Arizona.


Books:


Ralph Moss: Antioxidants Against Cancer

Ralph Moss: Albert Szent-Györgyi: Free Radical

Szent-Györgyi's Alpha and Beta States

Here's a concise summary of Szent-Györgyi's understanding of the alpha and beta states. The relevance to cancer may be apparent. Excerpted from and a synopsis of "Electronic Biology and Cancer; A New Theory of Cancer" by Albert Szent-Györgyi.


Properties of resting (ß) and proliferative (α) states in cells (scroll down; blogspot does not like tables)

α State	ß State
High D/A, low pε	Low D/A, high pε
Unbridled proliferation	Regulation of cell division
Undifferentiated, molecular dispersion	Differentiated
lack of structures	insoluble structures
Soluble proteins	Insoluble proteins
No contact inhibition	Contact inhibition
Fermentation	Oxidation
No carbonyls	carbonyls and carbonyl-biogen amine
Free SH	Complexed SH
Anaerobic reactions	Aerobic reactions
dark	photosynthesis
Dielectric	Semiconductor
Closed-shell molecules	Charge transfer complexes
molecular reactions	Free radicals, electronic reactions
Structured water	Random water
Lack of color	Colored
Fetal proteins	No fetal proteins

Is Man the Ultimate Semiconductor; Does a "Cheap, Safe," Drug Kill Most Cancers?

Lately the New Scientist has been all atwitter about the notion that a "Cheap, 'safe,' drug kills most cancers."

To quote the article:

"Evangelos Michelakis of the University of Alberta in Edmonton, Canada, and his colleagues tested DCA (dichloroacetate) on human cells cultured outside the body and found that it killed lung, breast and brain cancer cells, but not healthy cells. Tumours in rats deliberately infected with human cancer also shrank drastically when they were fed DCA-laced water for several weeks."

and:

"Paul Clarke, a cancer cell biologist at the University of Dundee in the UK, says the findings challenge the current assumption that mutations, not metabolism, spark off cancers. “The question is: which comes first?” he says."

Of course, at present we don't know if DCA works or not; we hope it does, but a few things are interesting.

If DCA works, it may vindicate the work of two Nobel Laureates who spent a lot of time thinking about cancer, but whose ideas have faded into oblivion: Otto Warburg, who first discovered that the metabolic processes in healthy cells and in cancer cells are completely different, and Albert Szent-Györgyi, who devoted the later years of his life to studying what life, and cancer is. Szent-Györgyi came to an understanding of life that is substantially more subtle than that of many people in his, and our, time.

What does this have to do with DCA? Szent-Györgyi came to understand life, and pathologies of life such as cancer, not merely as a material or molecular processes, but also as an energetic, electronic, or submolecular processes. He noted that:

• life on this planet has existed in two forms, and what he called the "alpha form" which originated in an oxygen free environment, and is anaerobic in its metabolism (the fermentation seen in mitochondria and cancer cells,) and what he called the "beta form," which evolved later, and is aerobic (that is relies on oxidation.)
  
• living substances have ESR signatures (proof of electronic activity) that are quite different from inanimate objects, and noted that comparable cancer cells do not have normal, and sometimes not even discernible ESR signatures.
• contrary to the wide-spread belief that these ESR signatures, and the free radicals that cause them, are "artifacts" of rare processes, they, and the electron transfer in various organs that they prove is happening, is central to the health and functioning of the body.
  

Szent-Györgyi believed that life is much more subtle than the textbooks of his day would have, and that the process of life also involves making changes to the configuration of the electron shells of proteins and more. In the jargon of today's computer scientists, man is a semiconductor and "quantum computer." Szent-Györgyi believed that life uses some chemicals to "dope" the proteins that make up or body, that is to allow them to more easily transfer electrons, just as silicon and germanium semi-conductors are manufactured with inherent impurities, without which the chips made from them would be useless. Interestingly enough, DCA's chemical structure is far from entirely dissimilar to that of the substance which he discussed as the primary doping agent.

If Warburg and Szent-Györgyi prove to have been correct, it will open some extremely interesting new vistas into our understanding of life, health, and the treatment of cancer.


Books: Albert Szent-Györgyi Living State and Cancer. Workshop of the Natl Foundation for Cancer Research, and Marine Biological Lab, Woods Hole, Mass